منابع مشابه
Randomized and nonrandomized clinical studies: statistical considerations.
THE article in this issue of ANESTHESIOLOGY by O'Hara et aL1 provides a good opportunity to review different clinical study designs and statistical issues associated with analyzing data from randomized and nonrandomized comparative studies. Statistics are necessary to analyze clinical data because the response to intervention usually varies widely among patients.' Most biostatisticians favor th...
متن کاملAnalyzing Data from Nonrandomized Group Studies
Researchers evaluating prevention and early intervention programs must often rely on diverse study designs that assign groups to various study conditions (e.g., intervention versus control). Although the strongest designs randomly assign these groups to conditions, researchers frequently must use nonrandomized research designs in which assignments are made based on the characteristics of the gr...
متن کاملDifficulties in demonstrating superiority of an antibiotic for multidrug-resistant bacteria in nonrandomized studies.
The discovery and development of new antimicrobials is critically important, especially as multidrug-resistant bacteria continue to emerge. Little has been written about the epidemiological issues in nonrandomized trials aiming to evaluate the superiority of one antibiotic over another. In this manuscript, we outline some of the methodological difficulties in demonstrating superiority and discu...
متن کاملOn guidelines for comparative effectiveness research using nonrandomized studies in secondary data sources.
Objectives: Health insurers, physicians, and patients worldwide need information on the comparative effectiveness and safety of prescription drugs in routine care. Nonrandomized studies of treatment effects using secondary databases may supplement the evidence based from randomized clinical trials and prospective observational studies. Recognizing the challenges to conducting valid retrospectiv...
متن کاملMeta-analytic comparison of randomized and nonrandomized studies of breast cancer surgery.
BACKGROUND Randomized controlled trials (RCTs) are thought to provide the most accurate estimation of "true" treatment effect. The relative quality of effect estimates derived from nonrandomized studies (nRCTs) remains unclear, particularly in surgery, where the obstacles to performing high-quality RCTs are compounded. We performed a meta-analysis of effect estimates of RCTs comparing surgical ...
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ژورنال
عنوان ژورنال: Journal of Primary Care & Community Health
سال: 2010
ISSN: 2150-1327,2150-1327
DOI: 10.1177/2150131910374718